Sustralis
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“Building groundbreaking molecules for innovative solutions.”

Sophisticated and complex molecules as substrates for specific enzymes.

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#WEARESCIENCES

We are a company founded in 2022, combining biotechnology with organic chemistry to develop complex fluorogenic and chromogenic molecules. These molecules are key substrates in the  development of enzyme detection assays with applications in the in vitro diagnostics, food, and life sciences industries.

communication

Clear and transparent
communication

We promote precise and concrete exchanges that ensure transparency at every stage of the process.

Excellence in
execution

We guarantee flawless development from conception to final delivery, providing our clients with confidence and reliability.

Commitment to improvement

We are always ready to take on new challenges with dedication and professionalism.

Passion in
everything we do

We approach every task with enthusiasm, reflecting our commitment to quality and results.

communication

Clear and transparent
communication

We promote precise and concrete exchanges that ensure transparency at every stage of the process.

Excellence in
execution

We guarantee flawless development from conception to final delivery, providing our clients with confidence and reliability.

Commitment to improvement

We are always ready to take on new challenges with dedication and professionalism.

Passion in
everything we do

We approach every task with enthusiasm, reflecting our commitment to quality and results.

#MISSION

  • To design and create complex molecules using advanced biotechnology applied to organic chemistry.
  • To optimize processes to be more efficient, cost-effective, and sustainable.
  • To commit to meeting clients’ needs with exclusive technologies in Latin America

#VISION

  • To expand our product portfolio in the coming years by incorporating high-value molecules for the in vitro diagnostics and food industries.
  • To collaborate closely with our clients to achieve these goals.

We’re always ready to help you!

#OURPRODUCTS

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Alpha-MUG

4-Methylumbelliferyl α-D-glucopyranoside

CAS 17833-43-1

A fluorogenic substrate that ensures precise detection of α-glucosidic enzymatic activity, emitting bright blue fluorescence for advanced biochemical, diagnostic, and pharmacological applications.

Main applications
PACK PRICES

100 mg
US$60

250 mg
US$138

500 mg
US$253

1 g
US$381

BULK
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Beta-MUG

4-Methylumbelliferyl-β-D-glucopyranoside

CAS 18997-57-4

A versatile fluorescent compound for enzymatic detection and microbiological analysis, trusted in industrial and scientific applications.

Industrial applications
Applications in biomedicine
PACK PRICES

500 mg
US$79

1 g
US$138

5 g
US$239

10 g
US$429

BULK
Request Quotation

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    Sustralis logo

    Headquarter

    Colectora Oeste RN9 – Km. 280 CP2130
    Parque Industrial Micropi, Alvear, Santa Fe

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    Main applications

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    α-MUG

    CAS 17833-43-1

    4-Methylumbelliferyl-α-D-glucopyranoside (4-MU-α-D-Glc) is a fluorogenic substrate used to detect and measure the activity of specific enzymes that hydrolyze α-glucosidic bonds, such as α-glucosidases. This compound is particularly useful in biochemical, diagnostic, and pharmacological applications due to its high sensitivity and specificity. The enzyme α-glucosidase hydrolyzes the α-glucosidic bond, releasing the fluorophore 4-MU. The 4-MU emits blue fluorescence (~450 nm) when excited with ultraviolet light (~365 nm). The fluorescence intensity is proportional to the enzymatic activity.

    Biochemical Research
    Study of α-Glucosidases:

    It is used to evaluate the activity of α-glucosidases in various biological samples, such as tissues or cell cultures.
    It allows the study of enzyme kinetics (𝑉max,𝐾𝑚) and the regulation of these enzymes.

    Medical Diagnosis
    Diseases Related to α-Glucosidases:

    Pompe Disease:
    The deficiency of acid α-glucosidase (GAA) causes glycogen accumulation in lysosomes. 4-MU-α-D-Glc is a common substrate used to measure GAA activity in fibroblasts or leukocytes for the diagnosis of this lysosomal disease.
    Monitoring Therapies:
    Evaluation of the effectiveness of enzyme replacement therapies (ERT) in patients with Pompe disease.

    Pharmacological Research
    Development of α-Glucosidase Inhibitors:

    α-Glucosidases are involved in carbohydrate digestion and glucose metabolism. 4-MU-α-D-Glc is used in high-throughput assays to identify and characterize inhibitors that could be useful in the treatment of type 2 diabetes and other metabolic diseases.

    Microbiology
    Identification of Microorganisms:

    Some bacteria and fungi produce specific α-glucosidases that can be detected using this substrate, facilitating their identification in microbiological studies.

    Industrial Biotecnology
    Optimization of Bioprocesses:

    It is used to monitor the activity of α-glucosidases in fermentation processes and industrial enzyme production.
    It is also used in the manufacture of biological indicators for sterilization to assess the effectiveness of processes such as steam sterilization, ethylene oxide, among others. This compound acts as a substrate to detect the activity of α-glucosidase, present in certain highly resistant microorganisms.

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    Main applications

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    β-MUG

    CAS 18997-57-4

    4-Methylumbelliferyl-β-D-glucopyranoside (4-MUG) is a fluorescent compound widely used in various industrial and scientific applications, particularly in areas related to enzymatic detection and microbiological analysis.

    Microbiological Diagnosis
    Identification of Coliforms and E. coli:

    4-MUG is used to detect the activity of the enzyme β-glucuronidase, which is present in many bacteria, including Escherichia coli. In culture media, β-glucuronidase hydrolyzes 4-MUG, releasing 4-methylumbelliferone (4-MU), a fluorescent compound that emits blue light under UV light. This enables rapid and specific detection of E. coli in food, drinking water, and wastewater.

    Quality Control in Food and Beverages

    In the food industry, 4-MUG is used to monitor microbial contamination in dairy products, meat, juices, and other processed foods. Its ability to detect indicator microorganisms like E. coli makes it an essential tool for ensuring food safety.

    Environmental Monitoring

    In water treatment plants and environmental studies, 4-MUG is employed to analyze the microbiological quality of water, allowing for the identification of fecal contamination by detecting E. coli.

    Pharmaceutical and Biotechnological Production
    Enzyme Assays:

    In the pharmaceutical industry, 4-MUG is used to study the activity of β-glucuronidases, an enzyme of interest in research on drug metabolism, metabolic diseases, and cancer. Its use allows for the evaluation of enzymatic activity under specific conditions and facilitates the design of new drugs or therapies.

    Industrial Process Control

    In industrial fermentation processes, such as the production of biofuels or enzymes, 4-MUG can be used to monitor the presence of specific microorganisms or measure β-glucuronidase activity in real-time, optimizing process efficiency.
    It is also widely used in the production of biological indicators for sterilization and cleaning processes. This compound helps assess the effectiveness of these procedures by detecting the enzymatic activity of β-glucuronidase, an enzyme found in specific microorganisms used in these indicators.

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    Applications in biomedicine

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    Beta-MUG

    CAS 18997-57-4

    Clinical Diagnosis
    Identification of Bacterial Infections:

    4-MUG is used to detect the presence of Escherichia coli and other β-glucuronidase-producing bacteria in clinical samples such as urine, stool, and bodily fluids.
    Example: In urine cultures, the hydrolysis of 4-MUG by bacterial β-glucuronidase generates fluorescence, enabling rapid and specific diagnosis of urinary tract infections (UTIs).

    Lysosomas Diseases
    Lysosomal Storage Studies:

    4-MUG is used to measure β-glucuronidase activity in tissue or cell samples. β-Glucuronidase is a crucial enzyme in glycosaminoglycan metabolism, and its deficiency is associated with lysosomal diseases such as mucopolysaccharidosis type VII (Sly syndrome).
    Use: The 4-MUG-based assay confirms reduced enzyme activity in these diseases, facilitating diagnosis.

    Oncology
    Tumor marker:

    In certain types of cancer, such as liver or colon tumors, elevated β-glucuronidase activity has been observed compared to normal tissues.
    Use: 4-MUG can assist in research on tumor localization and progression by detecting increased enzymatic activity.

    Drug Metabolism Research
    Drug Release Studies:

    β-Glucuronidase is also involved in the hydrolysis of glucuronidated drug metabolites in the body. 4-MUG is used in assays to study this process, which is essential for understanding the pharmacokinetics of certain medications.

    Metabolic Disease Diagnosis
    Diseases Related to Glucuronidase Enzymes:

    Alterations in β-glucuronidase activity may be implicated in metabolic disorders. Assays with 4-MUG enable the evaluation of enzymatic function in patients and establish correlations with pathological states.

    Clinical Microbiology
    Detection of Bacteria in Gastrointestinal Diseases:

    In stool samples, 4-MUG is used for the rapid detection of E. coli, including pathogenic strains like E. coli O157:H7, which can cause severe diseases such as hemorrhagic diarrhea or hemolytic uremic syndrome.

    Personalized Therapies

    In gene therapy or enzyme replacement therapy research, 4-MUG is used to monitor the restoration of β-glucuronidase activity in treated cells, evaluating the effectiveness of these interventions.